Benadryl and memory loss, These studies were done on those who took anticholinergics long term as many of us have. But the class of medications Benadryl belongs to is linked to dementia. Mar 27, 2024 · Does Long-Term Benadryl Use Increase Dementia Risk? Benadryl, which contains diphenhydramine, is a drugstore mainstay and just one medication out of many that could possibly damage brain health Jan 9, 2026 · The study found that taking Benadryl, a class of medications, is linked to dementia. Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. May 22, 2013 · A study with internal validity only to African-Americans over the age of 70 which “suggested†that anticholinergic use may be linked to mild cognitive impairment had, through the evolution of information, been applied to the general population and concluded that medications like Benadryl caused memory loss. Feb 26, 2024 · Medically Reviewed Does Benadryl Cause Dementia? Long-term use of the drug has been associated with an increased risk of cognitive impairment and memory loss, but more research is needed. Anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and drugs to relieve the symptoms of Parkinson's disease. Jan 10, 2025 · Benadryl works by blocking histamine receptors to reduce itching, swelling, and mucus production. In the rest of the body, it stimulates muscle contractions. Jan 9, 2025 · In the brain, acetylcholine is involved in learning and memory. Dec 21, 2024 · Dementia is a condition characterized by loss of memory and cognitive function. May 29, 2024 · The Benadryl-Dementia Debate The concern surrounding Benadryl and other anticholinergic medications stems from studies suggesting a potential association between long-term use of these drugs and an increased risk of dementia in older adults. While the general view is that medication-caused memory problems are reversible upon medication discontinuation, new evidence is linking long-term use to increased risk of dementia. Benadryl Side Effects on Brain Health and Dementia Risk First-generation antihistamines like diphenhydramine (Benadryl) block histamine but also strongly block acetylcholine, a neurotransmitter essential for attention and memory. If you need to take Benadryl, you can follow a few precautions to lower any potential risk. Caution should be exercised for long-term use of Benadryl (diphenhydramine), an antihistamine and a non-benzodiazepine sedative-hypnotic, because of the association of increased risk for dementia. Apr 6, 2023 · Several studies have examined whether Benadryl can cause dementia. Learn how anticholinergic drugs may cause this illness. Mar 9, 2021 · Anticholinergics include among others antidepressants and Benadryl. Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson’s disease patients. It also blocks acetylcholine, a neurotransmitter essential for cognitive functions such as learning and memory. . Thoughts? Interested in more discussions like this? Go to the Depression & Anxiety Support Group. So far, the research hasn’t proven that taking Benadryl raises the risk of dementia. Although generally considered sedating, diphenhydramine can cause paradoxical central nervous system stimulation in some individuals, particularly at higher doses. Thus side effects such as grogginess, drowsiness, and memory loss are common. Diphenhydramine also has affinity for muscarinic and adrenergic receptors and readily penetrates the blood-brain-barrier.
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